HLA-DRB1*03, but not the TNFA -308 promoter gene polymorphism, confers protection against fistulising Crohn's disease.

doi:10.1007/s002510050382

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Article

HLA-DRB1*03, but not the TNFA -308 promoter gene polymorphism, confers protection against fistulising Crohn's disease.

Immunogenetics - 1 May 1998

Bouma G, Poen A C, García-González M A, Schreuder G M, Felt-Bersma R J, Meuwissen S G, Pena A S

Abstract excerpt

Crohn's disease (CD) appears in forms so diverse that it has been hypothesized CD might be a syndrome, with different pathogenic mechanisms leading to the various clinical phenotypes. This may plausibly explain the conflicting and inconclusive results with regard to HLA associations in unselected...

Topics

Alleles
Crohn Disease
Female
HLA-DR Antigens
HLA-DRB1 Chains
Humans
Male
Polymorphism, Genetic
Promoter Regions, Genetic
Tumor Necrosis Factor-alpha

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