Article
Oligodendroglial tau filament formation in transgenic mice expressing G272V tau.
The European journal of neuroscience - 1 Jun 2001
Götz J, Tolnay M, Barmettler R, Chen F, Probst A, Nitsch R M
Abstract excerpt
Genetic evidence indicates that several mutations in tau, including G272V, are linked to frontotemporal dementia with parkinsonism. We expressed this mutation in mouse brains by combining a prion protein promoter-driven expression system with an autoregulatory transactivator loop that resulted in high expression of human G272V tau in neurons and in oligodendrocytes. We show that G272V tau can form filaments in...
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