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Article

Conformational intermediate of the amyloidogenic protein beta 2-microglobulin at neutral pH.

The Journal of biological chemistry - 31 Aug 2001

Heegaard N H, Sen J W, Kaarsholm N C, Nissen M H

Abstract excerpt

Aggregation and fibrillation of beta(2)-microglobulin are hallmarks of dialysis-related amyloidosis. We characterize perturbations of the native conformation of beta(2)-microglobulin that may precede fibril formation. For a beta(2)-microglobulin variant cleaved at lysine 58, we show using capillary electrophoresis that two conformers spontaneously exist in aqueous buffers at neutral pH. Upon treatment of...

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PMID: 11418618
DOI: 10.1074/jbc.M104452200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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