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Article

Role of conformational change in the C-terminus of beta2-microglobulin in dialysis-related amyloidosis.

Annals of clinical biochemistry - 1 Sept 2008

Kim Jaemi, Motomiya Yoshihiro, Ueda Mitsuharu, Nakamura Masaaki, Misumi Yohei, Saito Shiori, Ikemizu Shinji, Misumi Shogo, Ota Kazutoshi, Shinriki Satoru, Kai Hirofumi, Ando Yukio

Abstract excerpt

BACKGROUND: Beta(2)-microglobulin (beta(2)m) has been identified as the precursor protein of dialysis-related amyloidosis (DRA), which is a serious complication for haemodialysis (HD) patients. However, mechanisms underlying beta(2)m amyloid fibril formation remains to be elucidated. We previously demonstrated, in amyloid deposits from HD patients, a conformational isoform of beta(2)m with an unfolded C-terminus....

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Identifiers

PMID: 18753422
DOI: 10.1258/acb.2008.008046

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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