Article
Interactions of charged ligands with beta(2)-microglobulin conformers in affinity capillary electrophoresis.
Biochimica et biophysica acta - 10 Nov 2005
Heegaard Niels H H, De Lorenzi Ersilia
Abstract excerpt
Alternative conformations of beta(2)-microglobulin (beta(2)m) are involved in its transformation from soluble monomeric precursor molecules to the insoluble polymeric material that constitutes beta(2)m amyloid. Accordingly, non-native conditions such as low pH or high ionic strength promote beta(2)m amyloid formation in vitro. The early events in these processes are not well known, partly because of the paucity...
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