Article
Two cyclophilin A homologs with shared and distinct functions important for growth and virulence of Cryptococcus neoformans.
EMBO reports - 1 Jun 2001
Wang P, Cardenas M E, Cox G M, Perfect J R, Heitman J
Abstract excerpt
Cyclophilin A is the target of the immunosuppressant cyclosporin A (CsA) and is encoded by a single unique gene conserved from yeast to humans. In the pathogenic fungus Cryptococcus neoformans, two homologous linked genes, CPA1 and CPA2, were found to encode two conserved cyclophilin A proteins. In contrast to Saccharomyces cerevisiae, in which cyclophilin A mutations confer CsA resistance but few other...
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