Article
Structural and evolutionary relationships among the immunophilins: two ubiquitous families of peptidyl-prolyl cis-trans isomerases.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Dec 1992
Trandinh C C, Pao G M, Saier M H
Abstract excerpt
The immunophilins, protein receptors for the immunosuppressing drugs cyclosporin A and FK506 and related proteins from plants, fungi, and bacteria, have been analyzed structurally and evolutionarily. The cyclosporin A binding proteins (cyclophilins) represent one ubiquitous family of homologous p...
Topics
- Amino Acid Isomerases
- Amino Acid Sequence
- Animals
- Biological Evolution
- Carrier Proteins
- Humans
- Molecular Sequence Data
- Mutation
- Peptidylprolyl Isomerase
- Phylogeny
- Receptors, Immunologic
- Tacrolimus Binding Proteins