Article
Cryptococcus neoformans mating and virulence are regulated by the G-protein alpha subunit GPA1 and cAMP.
Genes & development - 1 Dec 1997
Alspaugh J A, Perfect J R, Heitman J
Abstract excerpt
This study explores signal transduction pathways that function during mating and infection in the opportunistic, human fungal pathogen Cryptococcus neoformans. The gene encoding a G-protein alpha subunit homolog, GPA1, was disrupted by homologous recombination. The gpa1 mutant strain was viable b...
Topics
- Animals
- Cryptococcosis
- Cryptococcus neoformans
- Cyclic AMP
- Disease Models, Animal
- GTP-Binding Protein alpha Subunits
- GTP-Binding Protein alpha Subunits, Gq-G11
- GTP-Binding Proteins
- Genes, Fungal
- Heterotrimeric GTP-Binding Proteins
- Humans
- Male
- Melanins
- Meningitis, Fungal
- Mutagenesis
- Phenotype
- Rabbits
- Saccharomyces cerevisiae