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Article

Cryptococcus neoformans mating and virulence are regulated by the G-protein alpha subunit GPA1 and cAMP.

Genes & development - 1 Dec 1997

Alspaugh J A, Perfect J R, Heitman J

Abstract excerpt

This study explores signal transduction pathways that function during mating and infection in the opportunistic, human fungal pathogen Cryptococcus neoformans. The gene encoding a G-protein alpha subunit homolog, GPA1, was disrupted by homologous recombination. The gpa1 mutant strain was viable but exhibited a defect in mating in response to nitrogen starvation. Additionally, the gpa1 mutant strain failed to...

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Identifiers

PMID: 9389652
DOI: 10.1101/gad.11.23.3206
PMCID: PMC316752

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Cryptococcus neoformans mating and virulence are regulated by the G-protein alpha subunit GPA1 and cAMP.PMID 9389652Read ↗

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