Sensitivity to cyclosporin A is mediated by cyclophilin in Neurospora crassa and Saccharomyces cerevisiae.

doi:10.1038/342953a0

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Article

Sensitivity to cyclosporin A is mediated by cyclophilin in Neurospora crassa and Saccharomyces cerevisiae.

Nature - 1 Jan 2000

Tropschug M, Barthelmess I B, Neupert W

Abstract excerpt

Cyclosporin A, a cyclic fungal undecapeptide produced by Tolypocladium inflatum, is a potent immunosuppressive drug originally isolated as an antifungal antibiotic. Cyclosporin A (CsA) is widely used in humans to prevent rejection of transplanted organs such as kidney, heart, bone marrow and live...

Topics

Carrier Proteins
Cyclosporins
Cytosol
Drug Resistance, Microbial
Mitochondria
Mutation
Neurospora
Neurospora crassa
Peptidylprolyl Isomerase
Protein Binding
Saccharomyces cerevisiae

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