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Article

Sensitivity to cyclosporin A is mediated by cyclophilin in Neurospora crassa and Saccharomyces cerevisiae.

Nature - 1 Jan 2000

Tropschug M, Barthelmess I B, Neupert W

Abstract excerpt

Cyclosporin A, a cyclic fungal undecapeptide produced by Tolypocladium inflatum, is a potent immunosuppressive drug originally isolated as an antifungal antibiotic. Cyclosporin A (CsA) is widely used in humans to prevent rejection of transplanted organs such as kidney, heart, bone marrow and liver. The biochemical basis of CsA action is not known: its primary cellular target has been suggested to be calmodulin,...

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PMID: 2531848
DOI: 10.1038/342953a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Sensitivity to cyclosporin A is mediated by cyclophilin in Neurospora crassa and Saccharomyces cerevisiae.PMID 2531848Read ↗

Mutations that perturb cyclophilin A ligand binding pocket confer cyclosporin A resistance in Saccharomyces cerevisiae.Semantic proximity Read ↗

Genetic deficiency and polymorphisms of cyclophilin A reveal its essential role for Human Coronavirus 229E replication.Semantic proximity Read ↗

Structural and evolutionary relationships among the immunophilins: two ubiquitous families of peptidyl-prolyl cis-trans isomerases.Semantic proximity Read ↗

FK506-binding protein of Neurospora crassa (NcFKBP) mediates sensitivity to the immunosuppressant FK506; resistant mutants identify two loci.Semantic proximity Read ↗

Two cyclophilin A homologs with shared and distinct functions important for growth and virulence of Cryptococcus neoformans.Semantic proximity Read ↗

Cyclosporine A-resistant human immunodeficiency virus type 1 mutants demonstrate that Gag encodes the functional target of cyclophilin A.Semantic proximity Read ↗

The mutant Escherichia coli F112W cyclophilin binds cyclosporin A in nearly identical conformation as human cyclophilin.Semantic proximity Read ↗

The yeast FKS1 gene encodes a novel membrane protein, mutations in which confer FK506 and cyclosporin A hypersensitivity and calcineurin-dependent growth.Semantic proximity Read ↗

Current implications of cyclophilins in human cancersSemantic proximity Read ↗

A novel calcineurin-independent activity of cyclosporin A in Saccharomyces cerevisiae.Semantic proximity Read ↗

A mutation in alpha helix 3 of CA renders human immunodeficiency virus type 1 cyclosporin A resistant and dependent: rescue by a second-site substitution in a distal region of CA.Semantic proximity Read ↗

Immunophilins and Parvulins. Superfamily of Peptidyl Prolyl Isomerases in ArabidopsisSemantic proximity Read ↗

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