Article
Mutations that perturb cyclophilin A ligand binding pocket confer cyclosporin A resistance in Saccharomyces cerevisiae.
The Journal of biological chemistry - 8 Sept 1995
Cardenas M E, Lim E, Heitman J
Abstract excerpt
In complex with the peptidyl-prolyl isomerase cyclophilin A, the immunosuppressive antifungal drug cyclosporin A (CsA) inhibits a Ca2+/calmodulin-dependent protein phosphatase, calcineurin, which regulates signal transduction. We isolated and characterized cyclophilin A mutations that confer CsA...
Topics
- Amino Acid Isomerases
- Amino Acid Sequence
- Base Sequence
- Calcineurin
- Calmodulin-Binding Proteins
- Carrier Proteins
- Conserved Sequence
- Cyclosporine
- DNA, Fungal
- Drug Resistance, Microbial
- Humans
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Peptidylprolyl Isomerase
- Phosphoprotein Phosphatases
- Protein Binding
- Saccharomyces cerevisiae