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Article

Three loci modify growth of a transgene-induced mammary tumor: suppression of proliferation associated with decreased microvessel density.

Genomics - 15 Jun 2001

Le Voyer T, Rouse J, Lu Z, Lifsted T, Williams M, Hunter K W

Abstract excerpt

In earlier studies it was observed that the genetic background significantly affected the phenotype of a transgene-induced mammary tumor. Tumors arising in an (I/LnJ x PyMT) F1 hybrid background appeared earlier than in the FVB/N-TgN(MMTV-PyVT)(634Mul) parent, but accumulated less tumor mass, indicating a net decrease in tumor growth. Quantitative genetic mapping in a backcross identified three loci that were...

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Share to Blood Vessels
Share to Crosses, Genetic
Share to In Situ Nick-End Labeling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ki-67 Antigen

Share to Mammary Neoplasms, Experimental

Share to Mice, Inbred Strains

Share to Platelet Endothelial Cell Adhesion Molecule-1

Share to Quantitative Trait, Heritable

Source

Identifiers

PMID: 11414753
DOI: 10.1006/geno.2001.6562

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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