Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Cdc42-regulated actin cytoskeleton mediates Drosophila oocyte polarization.

Development (Cambridge, England) - 15 Jan 2013

Leibfried Andrea, Müller Sandra, Ephrussi Anne

Abstract excerpt

Polarity of the Drosophila oocyte is essential for correct development of the egg and future embryo. The Par proteins Par-6, aPKC and Bazooka are needed to maintain oocyte polarity and localize to specific domains early in oocyte development. To date, no upstream regulator or mechanism for localization of the Par proteins in the oocyte has been identified. We have analyzed the role of the small GTPase Cdc42 in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actin Cytoskeleton
Share to Biosensing Techniques
Share to Bridged Bicyclo Compounds, Heterocyclic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Polarity

Share to Fluorescence Resonance Energy Transfer

Share to Oogenesis

Share to Protein Kinase C

Share to Thiazolidines

Source

Identifiers

PMID: 23250210
DOI: 10.1242/dev.089250

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Cdc42-regulated actin cytoskeleton mediates Drosophila oocyte polarization.PMID 23250210Read ↗

CDC-42 regulates PAR protein localization and function to control cellular and embryonic polarity in C. elegans.Semantic proximity Read ↗

Cdc42 acts downstream of Bazooka to regulate neuroblast polarity through Par-6 aPKC.Semantic proximity Read ↗

Asymmetric positioning and organization of the meiotic spindle of mouse oocytes requires CDC42 function.Semantic proximity Read ↗

CDC-42 controls early cell polarity and spindle orientation in C. elegans.Semantic proximity Read ↗

Bazooka is required for polarisation of the Drosophila anterior-posterior axis.Semantic proximity Read ↗

Membrane targeting of Bazooka/PAR-3 is mediated by direct binding to phosphoinositide lipids.Semantic proximity Read ↗

Direct association of Bazooka/PAR-3 with the lipid phosphatase PTEN reveals a link between the PAR/aPKC complex and phosphoinositide signaling.Semantic proximity Read ↗

Advances in the study of CDC42 in the female reproductive systemSemantic proximity Read ↗

Cdc42 and Par proteins stabilize dynamic adherens junctions in the Drosophila neuroectoderm through regulation of apical endocytosis.Semantic proximity Read ↗

PAR-2, LGL-1 and the CDC-42 GAP CHIN-1 act in distinct pathways to maintain polarity in the C. elegans embryo.Semantic proximity Read ↗

Bazooka and atypical protein kinase C are required to regulate oocyte differentiation in the <i>Drosophila</i> ovarySemantic proximity Read ↗

The receptor-like tyrosine phosphatase lar is required for epithelial planar polarity and for axis determination within drosophila ovarian follicles.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.