Article
Emergence of vaccine-induced escape mutant of hepatitis B virus with multiple surface gene mutations in a Korean child.
Journal of Korean medical science - 1 Jun 2001
Lee K M, Kim Y S, Ko Y Y, Yoo B M, Lee K J, Kim J H, Hahm K B, Cho S W
Abstract excerpt
The S protein of hepatitis B virus is the principal component of virus envelope and the primary target of anti-HBs response. Mutants or variants that escape neutralization by anti-HBs have been selected during immunoprophylaxis of HBV after birth and liver transplantation. We investigated a case of a Korean child who was vaccinated at birth against hepatitis B and also given hepatitis B immunoglobulin, but...
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