Article

Quantum Chemical Calculations on Locked Nucleic Acid based Antisense Modifications: A Density Functional Theory (DFT) Study at Monomer Level

2020-07-16

Abstract excerpt

Antisense technology has been developed as the next generation drug discovery methodology by which unwanted gene expression can be inhibited by targeting mRNA specifically with antisense oligonucleotides. It has been observed that a good number of these molecules entered into clinical trials at a faster rate and some of them got approved. The computational studies of antisense modifications based on phosphoro...

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Literature Corpus work: 01023dec-e7fb-5f43-a545-51e4d964fdf0
DOI: 10.26434/chemrxiv.12661628.v1

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