Article
Reduced glutathione protect cells from ouabain toxicity.
Biochimica et biophysica acta - 15 Jun 2001
Capella L S, Gefé M, Silva E F, Morales M M, Affonso-Mitidieri O, Lopes A G, Rumjanek V M, Capella M A
Abstract excerpt
It is widely accepted that a prolonged ouabain blockade of the Na(+),K(+)-ATPase makes cells detach from each other and from the substrate, leading to their death and that cellular resistance to ouabain is due to the presence of isoforms of Na(+),K(+)-ATPase with low affinity to this glycoside. In the present work the effect of reduced glutathione in the response of two types of renal cells to ouabain: MDCK, a...
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