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Article

Modulation of cardiac Na+,K+-ATPase cell surface abundance by simulated ischemia-reperfusion and ouabain preconditioning.

American journal of physiology. Heart and circulatory physiology - 1 Jan 2013

Belliard Aude, Sottejeau Yoann, Duan Qiming, Karabin Jessa L, Pierre Sandrine V

Abstract excerpt

Na(+),K(+)-ATPase and cell survival were investigated in a cellular model of ischemia-reperfusion (I/R)-induced injury and protection by ouabain-induced preconditioning (OPC). Rat neonatal cardiac myocytes were subjected to 30 min of substrate and coverslip-induced ischemia followed by 30 min of simulated reperfusion. This significantly compromised cell viability as documented by lactate dehydrogenase release and...

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Identifiers

PMID: 23086991
DOI: 10.1152/ajpheart.00374.2012
PMCID: PMC3543687

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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