Article
Cytoprotection by glycine against ATP-depletion-induced injury is mediated by glycine receptor in renal cells.
The Biochemical journal - 1 Sept 2005
Pan Chao, Bai Xiaoming, Fan Leming, Ji Yong, Li Xiaoyu, Chen Qi
Abstract excerpt
It is known that glycine protects mammalian cells against ischaemic cell injury by preventing cellular membrane leakage. However, the molecular mechanisms have not yet been clearly elucidated. The purpose of the present study was to clarify whether GlyR (glycine receptor) acts as a key mediator in cytoprotection of glycine. cDNA encoding human GlyRa1 (a1-subunit of glycine receptor) was transfected into HEK-293...
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