Article
Carcinogenetic process in gallbladder mucosa with pancreaticobiliary maljunction (Review).
Oncology reports - 1 Jan 2000
Tsuchida Akihiko, Itoi Takao, Aoki Tatsuya, Koyanagi Yasuhisa
Abstract excerpt
Pancreaticobiliary maljunction (PBM) is a congenital anomaly with a high incidence of biliary tract carcinoma. Pathological findings strongly suggest that there is a hyperplasia-dysplasia-carcinoma sequence in carcinogenesis of PBM. A molecular biological analysis revealed high incidence of cellular proliferation activating factors such as TGF-alpha, COX-2 from the hyperplasia stage. In addition, cellular...
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