Article
Abnormal uterus with polycysts, accumulation of uterine prostaglandins, and reduced fertility in mice heterozygous for acyl-CoA synthetase 4 deficiency.
Biochemical and biophysical research communications - 22 Jun 2001
Cho Y Y, Kang M J, Sone H, Suzuki T, Abe M, Igarashi M, Tokunaga T, Ogawa S, Takei Y A, Miyazawa T, Sasano H, Fujino T, Yamamoto T T
Abstract excerpt
Arachidonate released by various stimuli is rapidly reesterified into membrane phospholipids initiated by acyl-CoA synthetase (ACS) and subsequent acyl-transfer reactions. ACS4 is an arachidonate-preferring enzyme abundant in steroidogenic tissues and postulated to modulate eicosanoid production. Female mice heterozygous for ACS4 deficiency become pregnant less frequently and produce small litters with extremely...
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