Article
The prostaglandin receptor EP4 triggers remodelling of the cardiovascular system at birth.
Nature - 6 Nov 1997
Nguyen M, Camenisch T, Snouwaert J N, Hicks E, Coffman T M, Anderson P A, Malouf N N, Koller B H
Abstract excerpt
Survival of newborn placental mammals depends on closure of the ductus arteriosus (DA), an arterial connection in the fetus which directs blood away from the pulmonary circulation and towards the placenta where oxygenation occurs. Here we show that morphological changes resulting in closure of the DA in mice are virtually identical to those observed in larger mammals, including humans, and that maintenance of the...
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