Article
Attenuated expression of MTR in both prenatally androgenized mice and women with the hyperandrogenic phenotype of PCOS.
PloS one - 1 Jan 2017
Lei Lei, Ding Lijun, Su Jing, Liu Mengyuan, Shi Qingqing, Zhou Jianjun, Sun Haixiang, Yan Guijun
Abstract excerpt
Polycystic ovary syndrome (PCOS) is a common endocrine, metabolic and heterogeneous disorder in women of reproductive age, the exact etiology of which remains unknown. To unravel the molecular mechanisms underlying the hyperandrogenic phenotype of PCOS, prenatally androgenized (PNA) mice were used to mimic this phenotype in women with PCOS. Using microarray analysis, 1188 differentially expressed genes, including...
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