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Article

Altered expression of TGFB receptors and mitogenic effects of TGFB in pancreatic carcinomas.

International journal of oncology - 1 Jul 2001

Jonson T, Albrechtsson E, Axelson J, Heidenblad M, Gorunova L, Johansson B, Höglund M

Abstract excerpt

Alteration of the transforming growth factor beta (TGFB) signalling pathway is important in pancreatic carcinogenesis, as shown by the frequent inactivation of the downstream target SMAD4. We recently analysed a series of pancreatic carcinoma cell lines with respect to alterations of five SMAD genes involved in TGFB signalling, and showed that SMAD4 was structurally rearranged in 42% of these. This pathway may,...

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Share to Carcinoma, Pancreatic Ductal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11408925

Genes

TGFBR2
SMAD4
ENG
TGFB1
TGFBR3
TGFB2
TGFB3
TGFBR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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