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Article

Impaired transforming growth factor β signalling in Barrett’s carcinogenesis due to frequent SMAD4 inactivation

20 Dec 2005

Abstract excerpt

BACKGROUND AND AIMS: Transforming growth factor beta (TGF-beta) is frequently involved in gastrointestinal carcinogenesis although its contribution to oesophageal adenocarcinoma (AC) and its precursor Barrett's oesophageal epithelium (BE) metaplasia are unclear. METHODS: Expression of TGF-beta signalling components was assessed by reverse transcription-polymerase chain reaction (PCR), western blot, and...

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Identifiers

PMID: 16368780
DOI: 10.1136/gut.2005.076430

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