Article
Expression profiling of the influence of RAS mutants on the TGFB1-induced phenotype of the pancreatic cancer cell line PANC-1.
Genes, chromosomes & cancer - 1 Mar 2004
Fensterer Heiko, Giehl Klaudia, Buchholz Malte, Ellenrieder Volker, Buck Anita, Kestler Hans A, Adler Guido, Gierschik Peter, Gress Thomas M
Abstract excerpt
Expression profiling analyses were used to elucidate the functional relevance of RAS proteins in mediating the effect of TGFB1 on the transcriptional phenotype of the pancreatic cancer cell line PANC-1. Despite the presence of one mutated KRAS2 allele in parental PANC-1 pancreatic cancer cells, RAS-dependent signal transduction remained susceptible to stimulation by EGF and TGFB1. To analyze the impact of RAS...
Topics
- Amino Acid Substitution
- Cell Line, Tumor
- Cluster Analysis
- Culture Media, Serum-Free
- DNA, Neoplasm
- Gene Expression Profiling
- Gene Expression Regulation, Neoplastic
- Genes, ras
- Humans
- Mutation