Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mice lacking mannose 6-phosphate uncovering enzyme activity have a milder phenotype than mice deficient for N-acetylglucosamine-1-phosphotransferase activity.

Molecular biology of the cell - 1 Oct 2009

Boonen Marielle, Vogel Peter, Platt Kenneth A, Dahms Nancy, Kornfeld Stuart

Abstract excerpt

The mannose 6-phosphate (Man-6-P) lysosomal targeting signal on acid hydrolases is synthesized by the sequential action of uridine 5'-diphosphate-N-acetylglucosamine: lysosomal enzyme N-acetylglucosamine-1-phosphotransferase (GlcNAc-1-phosphotransferase) and GlcNAc-1-phosphodiester alpha-N-acetylglucosaminidase ("uncovering enzyme" or UCE). Mutations in the two genes that encode GlcNAc-1-phosphotransferase give...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cathepsin D
Share to Golgi Apparatus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydrolases

Share to L Cells

Share to Lysosomes

Share to Phosphoric Diester Hydrolases

Share to Receptor, IGF Type 2

Share to Transferases (Other Substituted Phosphate Groups)

Source

Open in PubMed Open full text

Identifiers

PMID: 19710420
DOI: 10.1091/mbc.e09-05-0398
PMCID: PMC2762139

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mice lacking mannose 6-phosphate uncovering enzyme activity have a milder phenotype than mice deficient for N-acetylglucosamine-1-phosphotransferase activity.PMID 19710420Read ↗

Lysosomal hydrolase mannose 6-phosphate uncovering enzyme resides in the trans-Golgi network.Semantic proximity Read ↗

The normal phenotype of Pmm1-deficient mice suggests that Pmm1 is not essential for normal mouse development.Semantic proximity Read ↗

Mucolipidosis II is caused by mutations in GNPTA encoding the alpha/beta GlcNAc-1-phosphotransferase.Semantic proximity Read ↗

Enzyme-specific differences in mannose phosphorylation between GlcNAc-1-phosphotransferase αβ and γ subunit deficient zebrafish support cathepsin proteases as early mediators of mucolipidosis pathology.Semantic proximity Read ↗

Differential sorting of lysosomal enzymes in mannose 6-phosphate receptor-deficient fibroblasts.Semantic proximity Read ↗

Comparative pathology of murine mucolipidosis types II and IIIC.Semantic proximity Read ↗

Ultrastructural analysis of neuronal and non-neuronal lysosomal storage in mucolipidosis type II knock-in mice.Semantic proximity Read ↗

Endo-β-N-acetylglucosaminidase forms N-GlcNAc protein aggregates during ER-associated degradation in Ngly1-defective cells.Semantic proximity Read ↗

Lethality of mice bearing a knockout of the Ngly1-gene is partially rescued by the additional deletion of the Engase geneSemantic proximity Read ↗

Ablation of mouse phosphomannose isomerase (Mpi) causes mannose 6-phosphate accumulation, toxicity, and embryonic lethality.Semantic proximity Read ↗

The relative contribution of mannose salvage pathways to glycosylation in PMI-deficient mouse embryonic fibroblast cells.Semantic proximity Read ↗

Neither type of mannose 6-phosphate receptor is sufficient for targeting of lysosomal enzymes along intracellular routes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.