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Article

The Bloom's syndrome helicase stimulates the activity of human topoisomerase IIIalpha.

Nucleic acids research - 15 Nov 2002

Wu Leonard, Hickson Ian D

Abstract excerpt

Bloom's syndrome (BS) is a disorder associated with chromosomal instability and a predisposition to the development of cancer. The BS gene product, BLM, is a DNA helicase of the RecQ family that forms a complex in vitro and in vivo with topoisomerase IIIalpha. Here, we show that BLM stimulates th...

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Share to RecQ Helicases
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Share to DNA Helicases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12433984
DOI: 10.1093/nar/gkf611
PMCID: PMC137159

Genes

BLM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12433984-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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