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Article

The Bloom's syndrome helicase stimulates the activity of human topoisomerase IIIalpha.

Nucleic acids research - 15 Nov 2002

Wu Leonard, Hickson Ian D

Abstract excerpt

Bloom's syndrome (BS) is a disorder associated with chromosomal instability and a predisposition to the development of cancer. The BS gene product, BLM, is a DNA helicase of the RecQ family that forms a complex in vitro and in vivo with topoisomerase IIIalpha. Here, we show that BLM stimulates the ability of topoisomerase IIIalpha to relax negatively supercoiled DNA. Moreover, DNA binding analyses indicate that...

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Share to RecQ Helicases
Share to Adenosine Triphosphatases
Share to DNA Helicases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA, Single-Stranded

Share to DNA, Superhelical

Share to DNA Topoisomerases, Type I

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Source

Open in PubMed Open full text

Identifiers

PMID: 12433984
DOI: 10.1093/nar/gkf611
PMCID: PMC137159

Genes

BLM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Bloom's syndrome helicase stimulates the activity of human topoisomerase IIIalpha.PMID 12433984Read ↗

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