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Article

Mutator effects of overproducing DNA polymerase eta (Rad30) and its catalytically inactive variant in yeast.

Mutation research - 1 Jul 2001

Pavlov Y I, Nguyen D, Kunkel T A

Abstract excerpt

DNA polymerase eta synthesizes DNA in vitro with low fidelity. Based on this, here we report the effects of deletion or increased expression of yeast RAD30 gene, encoding for polymerase eta (Pol eta), on spontaneous mutagenesis in vivo. Deletion of RAD30 did not affect spontaneous mutagenesis. Overproduction of Rad30p was slightly mutagenic in a wild-type yeast strain and moderately mutagenic in strains with...

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Identifiers

PMID: 11406177
DOI: 10.1016/s0027-5107(01)00131-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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