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Article

Yeast mitochondrial DNA mutators with deficient proofreading exonucleolytic activity.

The EMBO journal - 1 Jul 1992

Foury F, Vanderstraeten S

Abstract excerpt

The MIP1 gene which encodes yeast mitochondrial DNA polymerase possesses in its N-terminal region the three motifs (Exo1, Exo2 and Exo3) which characterize the 3'-5' exonucleolytic domain of many DNA polymerases. By site directed mutagenesis we have substituted alanine or glycine residues for conserved aspartate residues in each consensus sequence. Yeast mutants were therefore generated that are capable of...

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Identifiers

PMID: 1321035
DOI: 10.1002/j.1460-2075.1992.tb05337.x
PMCID: PMC556747

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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