Article
A genome screen of families with multiple cases of prostate cancer: evidence of genetic heterogeneity.
American journal of human genetics - 1 Jul 2001
Hsieh C L, Oakley-Girvan I, Balise R R, Halpern J, Gallagher R P, Wu A H, Kolonel L N, O'Brien L E, Lin I G, Van Den Berg D J, Teh C Z, West D W, Whittemore A S
Abstract excerpt
We conducted a genomewide screen for prostate cancer-susceptibility genes on the basis of data from 98 families from the United States and Canada that had three or more verified diagnoses of prostate cancer among first- and second-degree relatives. We found a statistically significant excess of markers for which affected relatives exhibited modest amounts of excess allele-sharing; however, no single chromosomal...
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