Article
Finding prostate cancer susceptibility genes.
Annual review of genomics and human genetics - 1 Jan 2004
Ostrander Elaine A, Markianos Kyriacos, Stanford Janet L
Abstract excerpt
Prostate cancer is a heterogeneous disease with multiple loci contributing to susceptibility. Traditionally, genome-wide scans using high-risk families have utilized stratification by number of affected individuals, family history of other cancers, or family age at diagnosis to improve genetic homogeneity. In addition to locus heterogeneity, for later onset diseases such as prostate cancer, a major limitation to...
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