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Article

Neurotoxicity of channel mutations in heterologously expressed alpha7-nicotinic acetylcholine receptors.

The European journal of neuroscience - 1 May 2001

Lukas R J, Lucero L, Buisson B, Galzi J L, Puchacz E, Fryer J D, Changeux J P, Bertrand D

Abstract excerpt

Nicotinic acetylcholine receptors (nAChR) composed of chick alpha7 subunits mutated to threonine at amino acid valine-251 in the putative channel-lining M2 domain were expressed heterologously in several neuron-like and non-neuronal mammalian cell lines. Expression of mutant alpha7-nAChR is toxic to neuron-like cells of the human neuroblastoma cell lines SH-SY5Y and IMR-32, but not to several other cell types....

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Identifiers

PMID: 11403678
DOI: 10.1046/j.0953-816x.2001.01560.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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