Article
Co-expression of the neuronal alpha7 and L247T alpha7 mutant subunits yields hybrid nicotinic receptors with properties of both wild-type alpha7 and alpha7 mutant homomeric receptors.
Proceedings of the National Academy of Sciences of the United States of America - 18 Feb 1997
Palma E, Eusebi F, Miledi R
Abstract excerpt
Injection of cDNA encoding the neuronal alpha7 subunit into Xenopus oocytes yields homomeric receptors showing responses to AcCho that have low affinity, fast desensitization, nonlinear current-voltage (I-V) relation, and sensitivity to alpha-bungarotoxin (alpha-BTX) and 5-hydroxytryptamine (5HT), both substances acting as antagonists. Mutation of the Leu-247, located in the channel domain, changes 5HT from an...
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