Article
Cloning and characterization of three Xenopus slug promoters reveal direct regulation by Lef/beta-catenin signaling.
The Journal of biological chemistry - 10 Aug 2001
Vallin J, Thuret R, Giacomello E, Faraldo M M, Thiery J P, Broders F
Abstract excerpt
In amphibians and birds, one of the first steps of neural crest cell (NCC) determination is expression of the transcription factor Slug. This marker has been used to demonstrate that BMP and Wnt molecules play a major role in NCC induction. However, it is unknown whether Slug expression is directly or indirectly regulated by these signals. We report here the cloning and characterization of three Xenopus Slug...
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