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Article

A novel mechanism for the transcriptional regulation of Wnt signaling in development.

Genes & development - 1 Sept 2011

Vacik Tomas, Stubbs Jennifer L, Lemke Greg

Abstract excerpt

Axial patterning of the embryonic brain requires a precise balance between canonical Wnt signaling, which dorsalizes the nervous system, and Sonic hedgehog (Shh), which ventralizes it. The ventral anterior homeobox (Vax) transcription factors are induced by Shh and ventralize the forebrain through a mechanism that is poorly understood. We therefore sought to delineate direct Vax target genes. Among these, we...

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Identifiers

PMID: 21856776
DOI: 10.1101/gad.17227011
PMCID: PMC3175715

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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