beta-TrCP is a negative regulator of Wnt/beta-catenin signaling pathway and dorsal axis formation in Xenopus embryos.

doi:10.1016/s0925-4773(98)00134-8

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Article

beta-TrCP is a negative regulator of Wnt/beta-catenin signaling pathway and dorsal axis formation in Xenopus embryos.

Mechanisms of development - 1 Sept 1998

Marikawa Y, Elinson R P

Abstract excerpt

The Wnt/beta-catenin signaling pathway is responsible for the establishment of dorsoventral axis of Xenopus embryos. The recent finding of the F-box/WD40-repeat protein slimb in Drosophila, whose loss-of-function mutation causes ectopic activation of wingless signaling (Jiang, J., Struhl, G., 199...

Topics

Animals
Binding Sites
Body Patterning
Cytoskeletal Proteins
Embryo, Nonmammalian
GTP-Binding Proteins
Gene Expression Regulation, Developmental
Homeodomain Proteins
Mutation
Proto-Oncogene Proteins
Receptors, Transforming Growth Factor beta
Sequence Deletion
Signal Transduction
Trans-Activators
Transforming Growth Factor beta
Wnt Proteins
Xenopus
Xenopus Proteins

Source

Open in PubMed

Identifiers

PMID: 9784611
DOI: 10.1016/s0925-4773(98)00134-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9784611-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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