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Article

Acute hepatotoxicity of oncolytic adenoviruses in mouse models is associated with expression of wild-type E1a and induction of TNF-alpha.

Virology - 10 Oct 2004

Engler Heidrun, Machemer Todd, Philopena Jennifer, Wen Shu-Fen, Quijano Erlinda, Ramachandra Murali, Tsai Van, Ralston Robert

Abstract excerpt

Replication competent adenoviruses with various E1 modifications designed to restrict their replication to tumor cells are being evaluated as oncolytic agents in clinical trials. In mouse models, we observed that such oncolytic adenoviruses showed greater hepatotoxicity than E1-deleted adenovirus vectors following intravenous administration. Additional studies in congenic BALB/c, nude, and beige/Scid mice...

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Identifiers

PMID: 15380358
DOI: 10.1016/j.virol.2004.06.043

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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