Article
Genetic deletions of NCAM and PSA impair circadian function in the mouse.
Physiology & behavior - 1 May 2001
Shen H, Watanabe M, Tomasiewicz H, Glass J D
Abstract excerpt
The adult suprachiasmatic nuclei (SCN) express neural cell adhesion molecule (NCAM) that carries polysialic acid (PSA), a carbohydrate polymer which controls plastic cell-cell interactions in neural tissues. Expression of the three major isoforms of NCAM [180 (principal PSA carrier), 140, and 120 kDa) varies with developmental and physiological state. The requirements for NCAM and PSA in circadian timekeeping...
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