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Article

Protection against HIV-1 gp120-induced brain damage by neuronal expression of human amyloid precursor protein.

1 Apr 1995

Abstract excerpt

Expression of the HIV-1 envelope protein gp120 in brains of transgenic (tg) mice induces extensive neurodegeneration (Toggas, S. M., E. Masliah, E. M. Rockenstein, G. F. Rall, C. R. Abraham, and L. Mucke. 1994. Nature [Lond.]. 367:188-193.). To further analyze the pathogenesis of gp120-induced neurotoxicity and to assess the neuroprotective potential of human amyloid precursor proteins (hAPPs) in vivo, different...

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PMID: 7699335
DOI: 10.1084/jem.181.4.1551

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