Article
Phosphorylation of the yeast phospholipid synthesis regulatory protein Opi1p by protein kinase C.
The Journal of biological chemistry - 10 Aug 2001
Sreenivas A, Villa-Garcia M J, Henry S A, Carman G M
Abstract excerpt
Opi1p is a negative regulator of expression of phospholipid-synthesizing enzymes in the yeast Saccharomyces cerevisiae. In this work, we examined the phosphorylation of Opi1p by protein kinase C. Using a purified maltose-binding protein-Opi1p fusion protein as a substrate, protein kinase C activity was time- and dose-dependent, and dependent on the concentrations of Opi1p and ATP. Protein kinase C phosphorylated...
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