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Article

Casein kinase II phosphorylation of the yeast phospholipid synthesis transcription factor Opi1p.

The Journal of biological chemistry - 24 Feb 2006

Chang Yu-Fang, Carman George M

Abstract excerpt

The transcription factor Opi1p regulates phospholipid synthesis in the yeast Saccharomyces cerevisiae by repressing the expression of several UAS(INO)-containing genes (e.g. INO1). Opi1p repressor activity is most active in inositol-supplemented cells. Regulation of Opi1p repressor activity is mediated by multiple phosphorylations catalyzed by protein kinases A and C. In this work, we showed that Opi1p was also...

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Identifiers

PMID: 16407309
DOI: 10.1074/jbc.M513064200
PMCID: PMC1978165

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Casein kinase II phosphorylation of the yeast phospholipid synthesis transcription factor Opi1p.PMID 16407309Read ↗

Phosphorylation of the yeast phospholipid synthesis regulatory protein Opi1p by protein kinase C.Semantic proximity Read ↗

Opi1 mediates repression of phospholipid biosynthesis by phosphate limitation in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

Overproduction of the Opi1 repressor inhibits transcriptional activation of structural genes required for phospholipid biosynthesis in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

The OPI1 gene of Saccharomyces cerevisiae, a negative regulator of phospholipid biosynthesis, encodes a protein containing polyglutamine tracts and a leucine zipper.Semantic proximity Read ↗

Pleiotropic effects of the opi1 regulatory mutation of yeast: its effects on growth and on phospholipid and inositol metabolism.Semantic proximity Read ↗

Identification of novel dominant INO2c mutants with an Opi- phenotype.Semantic proximity Read ↗

The stability of the Opi1p repressor for phospholipid biosynthetic gene expression in Saccharomyces cerevisiae is dependent on its interactions with Scs2p and Ino2p.Semantic proximity Read ↗

Regulation of the yeast INO1 gene. The products of the INO2, INO4 and OPI1 regulatory genes are not required for repression in response to inositol.Semantic proximity Read ↗

Interaction between repressor Opi1p and ER membrane protein Scs2p facilitates transit of phosphatidic acid from the ER to mitochondria and is essential for INO1 gene expression in the presence of choline.Semantic proximity Read ↗

Isolation and characterization of a mutant of Saccharomyces cerevisiae with pleiotropic deficiencies in transcriptional activation and repression.Semantic proximity Read ↗

Autoregulated expression of the yeast INO2 and INO4 helix-loop-helix activator genes effects cooperative regulation on their target genes.Semantic proximity Read ↗

Yet1p-Yet3p interacts with Scs2p-Opi1p to regulate ER localization of the Opi1p repressor.Semantic proximity Read ↗

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