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Article

Pleiotropic effects of the opi1 regulatory mutation of yeast: its effects on growth and on phospholipid and inositol metabolism.

Microbiology (Reading, England) - 1 Oct 1998

Jiranek Vladimir, Graves J Anthony, Henry Susan A

Abstract excerpt

Key factors which impact on the biosynthesis and subsequent fate of the phospholipid precursor inositol were studied as a function of growth phase in the yeast Saccharomyces cerevisiae. Both wild-type and strains disrupted for the OPI1 gene, the principal negative regulator of the phospholipid biosynthetic genes, were examined. Overexpression of the INO1 gene and overproduction of both inositol and the major...

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PMID: 9802015
DOI: 10.1099/00221287-144-10-2739

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Pleiotropic effects of the opi1 regulatory mutation of yeast: its effects on growth and on phospholipid and inositol metabolism.PMID 9802015Read ↗

Regulation of the yeast INO1 gene. The products of the INO2, INO4 and OPI1 regulatory genes are not required for repression in response to inositol.Semantic proximity Read ↗

Interaction between repressor Opi1p and ER membrane protein Scs2p facilitates transit of phosphatidic acid from the ER to mitochondria and is essential for INO1 gene expression in the presence of choline.Semantic proximity Read ↗

The OPI1 gene of Saccharomyces cerevisiae, a negative regulator of phospholipid biosynthesis, encodes a protein containing polyglutamine tracts and a leucine zipper.Semantic proximity Read ↗

Overproduction of the Opi1 repressor inhibits transcriptional activation of structural genes required for phospholipid biosynthesis in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

Opi1 mediates repression of phospholipid biosynthesis by phosphate limitation in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

Regulation of yeast phospholipid biosynthetic gene expression in response to inositol involves two superimposed mechanisms.Semantic proximity Read ↗

Genome-wide screen for inositol auxotrophy in Saccharomyces cerevisiae implicates lipid metabolism in stress response signaling.Semantic proximity Read ↗

Genome expression analysis in yeast reveals novel transcriptional regulation by inositol and choline and new regulatory functions for Opi1p, Ino2p, and Ino4p.Semantic proximity Read ↗

Identification of novel dominant INO2c mutants with an Opi- phenotype.Semantic proximity Read ↗

Genomic analysis of the Opi- phenotype.Semantic proximity Read ↗

Casein kinase II phosphorylation of the yeast phospholipid synthesis transcription factor Opi1p.Semantic proximity Read ↗

Isolation and characterization of a mutant of Saccharomyces cerevisiae with pleiotropic deficiencies in transcriptional activation and repression.Semantic proximity Read ↗

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