Article
Genomic analysis of the Opi- phenotype.
Genetics - 1 Jun 2006
Hancock Leandria C, Behta Ryan P, Lopes John M
Abstract excerpt
Most of the phospholipid biosynthetic genes of Saccharomyces cerevisiae are coordinately regulated in response to inositol and choline. Inositol affects the intracellular levels of phosphatidic acid (PA). Opi1p is a repressor of the phospholipid biosynthetic genes and specifically binds PA in the endoplasmic reticulum. In the presence of inositol, PA levels decrease, releasing Opi1p into the nucleus where it...
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