Article
The OPI1 gene of Saccharomyces cerevisiae, a negative regulator of phospholipid biosynthesis, encodes a protein containing polyglutamine tracts and a leucine zipper.
The Journal of biological chemistry - 15 Jan 1991
White M J, Hirsch J P, Henry S A
Abstract excerpt
In Saccharomyces cerevisiae, recessive mutations at the OPI1 locus result in constitutively derepressed expression of inositol 1-phosphate synthase, the product of the INO1 gene. Many of the other enzymes involved in phospholipid biosynthesis are also expressed at high derepressed levels in opi1 mutants. Thus, the OPI1 gene is believed to encode a negative regulator that is required to repress a whole subset of...
Topics
- Alleles
- Amino Acid Sequence
- Base Sequence
- Blotting, Southern
- Cloning, Molecular
- Genes, Fungal
- Glutamine
- Leucine Zippers
- Molecular Sequence Data
- Phospholipids
- RNA, Fungal