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Article

The OPI1 gene of Saccharomyces cerevisiae, a negative regulator of phospholipid biosynthesis, encodes a protein containing polyglutamine tracts and a leucine zipper.

The Journal of biological chemistry - 15 Jan 1991

White M J, Hirsch J P, Henry S A

Abstract excerpt

In Saccharomyces cerevisiae, recessive mutations at the OPI1 locus result in constitutively derepressed expression of inositol 1-phosphate synthase, the product of the INO1 gene. Many of the other enzymes involved in phospholipid biosynthesis are also expressed at high derepressed levels in opi1 mutants. Thus, the OPI1 gene is believed to encode a negative regulator that is required to repress a whole subset of...

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PMID: 1985968

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The OPI1 gene of Saccharomyces cerevisiae, a negative regulator of phospholipid biosynthesis, encodes a protein containing polyglutamine tracts and a leucine zipper.PMID 1985968Read ↗

Overproduction of the Opi1 repressor inhibits transcriptional activation of structural genes required for phospholipid biosynthesis in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

Identification of novel dominant INO2c mutants with an Opi- phenotype.Semantic proximity Read ↗

Pleiotropic effects of the opi1 regulatory mutation of yeast: its effects on growth and on phospholipid and inositol metabolism.Semantic proximity Read ↗

Regulation of the yeast INO1 gene. The products of the INO2, INO4 and OPI1 regulatory genes are not required for repression in response to inositol.Semantic proximity Read ↗

INO1-100: an allele of the Saccharomyces cerevisiae INO1 gene that is transcribed without the action of the positive factors encoded by the INO2, INO4, SWI1, SWI2 and SWI3 genes.Semantic proximity Read ↗

The stability of the Opi1p repressor for phospholipid biosynthetic gene expression in Saccharomyces cerevisiae is dependent on its interactions with Scs2p and Ino2p.Semantic proximity Read ↗

Interaction between repressor Opi1p and ER membrane protein Scs2p facilitates transit of phosphatidic acid from the ER to mitochondria and is essential for INO1 gene expression in the presence of choline.Semantic proximity Read ↗

Casein kinase II phosphorylation of the yeast phospholipid synthesis transcription factor Opi1p.Semantic proximity Read ↗

Regulation of yeast phospholipid biosynthetic gene expression in response to inositol involves two superimposed mechanisms.Semantic proximity Read ↗

Saccharomyces cerevisiae essential genes with an Opi- phenotype.Semantic proximity Read ↗

Genomic analysis of the Opi- phenotype.Semantic proximity Read ↗

The Saccharomyces cerevisiae INO4 gene encodes a small, highly basic protein required for derepression of phospholipid biosynthetic enzymes.Semantic proximity Read ↗

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