Article
Inhibition of volume-regulated anion channels by dominant-negative caveolin-1.
Biochemical and biophysical research communications - 8 Jun 2001
Trouet D, Hermans D, Droogmans G, Nilius B, Eggermont J
Abstract excerpt
Caveolae are flask-shaped invaginations of the plasma membrane formed by the association of caveolin proteins with lipid rafts. In endothelial cells, caveolae function as signal transduction centers controlling NO synthesis and mechanotransduction. We now provide evidence that the endothelial volume-regulated anion channel (VRAC) is also under the control of the caveolar system. When calf pulmonary artery...
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