Targeting of IgMkappa antibodies to oligodendrocytes promotes CNS remyelination.

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Article

Targeting of IgMkappa antibodies to oligodendrocytes promotes CNS remyelination.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Oct 1998

Asakura K, Miller D J, Pease L R, Rodriguez M

Abstract excerpt

We previously identified the remyelinating activity of a natural IgMkappa oligodendrocyte-reactive autoantibody (SCH94.03), using a virus-induced murine model of multiple sclerosis. We now describe a second mouse IgMkappa monoclonal antibody (mAb) (SCH79.08) raised against normal mouse spinal cor...

Topics

Animals
Antibodies, Monoclonal
Antigens, Viral
Autoantibodies
Blotting, Western
Brain
DNA, Complementary
Demyelinating Diseases
Disease Models, Animal
Enzyme-Linked Immunosorbent Assay
Epitopes
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunoglobulin M

Immunoglobulin Variable Region

Mice

Mice, Inbred Strains

Myelin Sheath

Nerve Regeneration

Source

Open in PubMed Open full text

Identifiers

PMID: 9742140
PMCID: PMC6793011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9742140-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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