Article
In vivo expression of major histocompatibility complex molecules on oligodendrocytes and neurons during viral infection.
The American journal of pathology - 1 Oct 2001
Redwine J M, Buchmeier M J, Evans C F
Abstract excerpt
Demyelination in multiple sclerosis and in animal models is associated with infiltrating CD8+ and CD4+ T cells. Although oligodendrocytes and axons are damaged in these diseases, the roles T cells play in the demyelination process are not completely understood. Antigen-specific CD8+ T cell lysis of target cells is dependent on interactions between the T cell receptor and major histocompatibility complex (MHC)...
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