Article
Non-involvement of the K-ras mutation in colon carcinogenesis promoted by dietary deoxycholate in azoxymethane-treated rats.
Bioscience, biotechnology, and biochemistry - 1 Apr 2001
Kanamoto R, Azuma N, Tsuchihashi Y, Suda H, Saeki T, Iwami K
Abstract excerpt
Fisher-344 rats, whose ileum or jejunum had been surgically removed to change the influx of bile acids into the colon, were intraperitoneally administered with azoxymethane and fed on a diet containing deoxycholate for 39 weeks to induce colon cancer. Fecal bile acids in the ileum-resected group were 1.5-times and serum bile acids were about half of those in the jejunum-resected group. As a result, the incidence...
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