Article
Overexpression of heat-shock proteins reduces survival of Mycobacterium tuberculosis in the chronic phase of infection.
Nature medicine - 1 Jun 2001
Stewart G R, Snewin V A, Walzl G, Hussell T, Tormay P, O'Gaora P, Goyal M, Betts J, Brown I N, Young D B
Abstract excerpt
Elevated expression of heat-shock proteins (HSPs) can benefit a microbial pathogen struggling to penetrate host defenses during infection, but at the same time might provide a crucial signal alerting the host immune system to its presence. To determine which of these effects predominate, we constructed a mutant strain of Mycobacterium tuberculosis that constitutively overexpresses Hsp70 proteins. Although the...
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