Article
High-temperature protein G is an essential virulence factor of Leptospira interrogans.
Infection and immunity - 1 Mar 2014
King Amy M, Pretre Gabriela, Bartpho Thanatchaporn, Sermswan Rasana W, Toma Claudia, Suzuki Toshihiko, Eshghi Azad, Picardeau Mathieu, Adler Ben, Murray Gerald L
Abstract excerpt
Leptospira interrogans is a global zoonotic pathogen and is the causative agent of leptospirosis, an endemic disease of humans and animals worldwide. There is limited understanding of leptospiral pathogenesis; therefore, further elucidation of the mechanisms involved would aid in vaccine development and the prevention of infection. HtpG (high-temperature protein G) is the bacterial homolog to the highly conserved...
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