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Infection Biology of a Novel α-Crystallin of Mycobacterium tuberculosis: Acr2

1 Apr 2005

Abstract excerpt

Heat shock proteins assist the survival of Mycobacterium tuberculosis (MTB) but also provide a signal to the immune response. The gene most strongly induced by heat shock in MTB is Rv0251c, which encodes Acr2, a novel member of the alpha-crystallin family of molecular chaperones. The expression of acr2 increased within 1 h after infection of monocytes or macrophages, reaching a peak of 18- to 55-fold by 24 h....

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PMID: 15778386
DOI: 10.4049/jimmunol.174.7.4237

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